Janice A. Dominov, Ph.D


Skeletal Muscle Growth and Regeneration

Research Summary
Skeletal muscle cells are highly structured cells responsible for body movement and respiration. Following trauma or disease, muscle growth and repair occurs via activation of muscle progenitor cells resident among the muscle fibers. Small subsets of these have qualities of self-renewing “stem cells”, producing both myogenic precursors and more stem cells, and possibly cell types other than muscle cells. Our aim is to understand mechanisms of skeletal muscle growth, repair and survival, with specific interests in degenerative muscle diseases including Duchenne and congenital muscular dystrophies. Our focus is on factors that promote muscle survival, chemoattractant signals contributing to repair, and traits that define stem cell populations within skeletal muscle.

Research Support is from the National Institute of Arthritis and Musculoskeletal and Skin Diseases.


Selected Publications
Dominov JA, Kravetz AJ, Ardelt M, Kostek CA, Beermann ML, Miller JB. (2005) Muscle-specific BCL2 expression ameliorates muscle disease in laminin {alpha}2-deficient, but not in dystrophin-deficient, mice. Hum Mol Genet; 14(8):1029-40.

Girgenrath M, Dominov JA, Kostek CA, Miller JB. (2004) Inhibition of apoptosis improves outcome in a model of congenital muscular dystrophy. J Clin Invest; 114(11):1635-9.

Nowak JA, Malowitz J, Girgenrath M, Kostek CA, Kravetz AJ, Dominov JA, Miller JB. (2004) Immortalization of mouse myogenic cells can occur without loss of p16INK4a, p19ARF, or p53 and is accelerated by inactivation of Bax. BMC Cell Biol; 5(1):1.

Pavlath, G. K., Dominov, J. A., Kegley, K. M. & J. B. Miller. (2003) Regeneration of transgenic skeletal muscles with altered timing of expression of the basic helix-loop-helix muscle regulatory factorMRF4. Am J Pathol; 162:1685-1691.

Dominov, J. A., Houlihan-Kawamoto, C. A., Swap, C. J. & J. B. Miller. (2001) Pro- and anti-apoptotic members of the Bcl-2 family in skeletal muscle: a distinct role for Bcl-2 in later stages of myogenesis. Dev Dyn; 220:18-26.

Miller, J. B., Schaefer, L. & J. A. Dominov. (1999) Seeking muscle stem cells. Curr Top Dev Biol; 43:191-219.