Research Areas

BBRI scientists utilize multidisciplinary approaches to investigate biological and disease mechanisms in research areas of muscle contraction, cell shape and movement, cellular communication, embryonic development and regeneration, and protein function and modification.

Biophysics and Biochemistry

Protein splicing – Paulus
Membrane protein-protein interactions – Wohlrab
Thermodynamics of protein-protein interactions – Harrison, Langsetmo, Lehrer, Stafford, Sundberg
Cell Biology

Cell growth regulation – Emerson, Erhardt, Hansen, Rameh
Cell morphology and cytoskeletal dynamics – Coluccio, Dominguez, Hansen, Rameh
Cell motility – Coluccio, Dominguez, Goldberg, Hansen, Smith
Membrane receptors and signal transduction pathways – Emerson, Erhardt, Hansen, Harrison, Kitazawa, Morgan, Rameh
Muscle and non-muscle contractility – Coluccio, Dominguez, Graceffa, Lehrer, Morgan, Tao, Wang
Developmental Biology and Genetics

Cell death pathways – Dominov, Erhardt, Miller
Developmental signaling, proteoglycans and extracellular matrix – Emerson, Miller
Embryo implantation – Leavis, Gonzalez
Gene regulatory networks – Emerson
Labor and the control of uterine muscle contractility – Morgan
RNA processing – Sarkar
Skeletal muscle, neural and fat differentiation – Emerson, Miller, Rameh
Genomics and Proteomics

Kinomes – Goldberg, Smith
Immunology

Superantigens – Sundberg
Therapeutic vaccines – Raso
Muscle Physiology

Biochemistry of smooth, cardiac and skeletal muscle contraction– Grabarek, Ikemoto, Lehrer, Lu, Mabuchi, Tao, Wang
Signaling regulation of smooth muscle contractility – Dominguez, Kitazawa, Morgan, Tao
Structural Biology

Contractile proteins – Dominguez, Grabarek, Graceffa
Membrane receptors – Harrison
Membrane transport proteins – Harrison, Wohlrab
Signaling proteins – Dominguez, Harrison, Ikemoto, Tao
Toxins – Sundberg