Disease Models

Disease Models and Therapeutics Research

BBRI scientists utilize biochemical, cellular or animal models to discover the underlying causes of a diversity of human diseases. These disease models are providing a deeper understanding of how the body normally works and are leading to unprecedented opportunities for our scientists to develop novel drug, stem cell and gene therapeutics. Currently, BBRI scientists are working in their own labs and in partnerships with biotechnology and pharmaceutical companies to develop treatments for tuberculosis, toxic shock syndromes, cancer, Alzheimer’s disease, obesity, preterm labor, fertility, cardiomyopathies, and vascular disease. For more information on any of these disease models and therapeutics, please contact the Public Affairs office at 617-658-7711.

Bacterial Pathogenesis

Bacterial toxins and superantigens – Sundberg
Tuberculosis – Paulus
Virulence genes – Sarkar

Angiogenesis and tumor growth – Emerson, Harrison
Cell and tumor growth control – Erhardt, Rameh
Cell movement and tumor metastasis – Coluccio, Dominguez, Goldberg, Hansen, Smith
Tumor suppressor genes and cancer genetics – Emerson, Erhardt
Degenerative Diseases & Tissue Damage

Aging – Wohlrab
Alzheimer’s & neurodegenerative diseases – Raso
Cardiac ischemia – Erhardt
Hearing loss – Coluccio
Muscular dystrophies – Dominov, Miller
Myopathies – Ikemoto
Wound healing – Hansen
Metabolic Disorders

Diabetes – Gonzalez, Rameh, Wohlrab
Glycogen storage disease – Wohlrab
Obesity – Raso
Reproductive Health

Fertility – Gonzalez, Leavis
Neural and skeletal muscle birth defects – Emerson
Preterm labor – Morgan