The BBRI research faculty consists of 30 independent scientists using structural biology, cell biology, biochemistry, and genetic approaches to investigate fundamental cellular mechanisms and the underlying causes of specific human diseases. BBRI prides itself in providing an exceptionally collegial and interactive research environment that fosters a cross-fertilization of ideas and encourages collaborations, making the whole truly more than the sum of its parts. One area of collaborative research focuses on the physiological, molecular and biophysical mechanisms that regulate skeletal, cardiac, and smooth muscle contraction and the closely related problem of how non-muscle cells move. Closely interwoven areas of study include cellular signaling and gene regulatory mechanisms governing the growth, differentiation and survival in embryonic and adult tissues, the abnormal growth and behavior of cancer cells, and the repair and regeneration tissues responding to disease and physical damage, including muscular dystrophy, neural degenerative disease and diabetes. BBRI scientists seek to make fundamental discoveries through basic research that will lead to an understanding of human disease and the development of novel therapeutics.
One of the joys of basic research is that scientific discoveries often lead us into totally unexpected and exciting directions that allow our scientists to open and develop new research frontiers, making BBRI an exciting place to do discovery research.