Adel Mandl, M.D.
Postdoctoral research fellow

Education
University of Pecs Medical School, Pecs, Hungary, 2005

Lab
Peter Erhardt

Research Interests
Phosphoinositides mediate hormone and growth factor signaling, thereby determining cell proliferation, survival, metabolism, morphology and motility. In addition, impaired phosphoinositide signaling is directly involved in various diseases such as diabetes and cancer. My research activity currently focuses on how the cellular levels of the various phosphoinositides are regulated. The delicate balance of these lipid products are maintained by several kinases as well as phosphatases. To determine the endogenous role of lipid kinases and phosphatases, I use RNA interference technique to knock down the expression of these enzymes in different cells. Subsequently, I analyze the downstream signaling events by immunoblot and monitor the level of radioactively labeled lipid products by HPLC in response to growth factor stimulation. These studies will further elucidate the molecular mechanism of phosphoinositide signaling and will allow us to design novel strategies to treat or prevent diabetes and cancer.

Recent Publications:
Mandl, A., Sarkes, D., Carricaburu, V., Jung, V. & Rameh, L. Growth factor-independent accumulation of phosphoinositide 3-kinase (PI3K) lipids in differentiating 3T3-L6 myoblasts: distinct roles for Ship2 and PTEN. Mol Cell Biol, In review.

Contact Details:
email: mandl@bbri.org, tel. 617-658-7787