Victor A. Raso, Ph.D.
Senior Scientist
Alzheimer's disease
Email: raso at bbri.org

Research Summary
Alzheimer's disease is marked by a high density of senile plaques, whose principal component is the 42-residue b-amyloid peptide. In my lab, several B-amyloid peptide vaccines have been synthesized and formulated with a human-compatible alum ajuvant. Presently, Alzheimer's vaccines are being tested in chemical trials. We hope that our continued basic research on Alzheimer's disease will lead to practical breakthroughs for treating this presently incurable and socially devastating human malady.

Selected Publications
Sloane AJ, Raso V, Dimitrov DS, Xiao X, Deo S, Muljadi N, Restuccia D, Turville S, Kearney C, Broder CC, Zoellner H, Cunningham AL, Bendall L, Lynch GW. (2005) Marked structural and functional heterogeneity in CXCR4: separation of HIV-1 and SDF-1alpha responses. Immunol Cell Biol. 83(2), 129-43.

Raso, V. (2000) Intracellular targeting using bispecific antibodies. Meth. Mol. Med. 25, 37-50.

Lynch, G.W., Sloane, A.J., Raso, V., Lai, A. & A.L. Cunningham (1999) Direct evidence for native CD4 oligomers in lymphoid and monocytoid cells. Eur. J. Immunol. 29, 2590-2602.

Raso, V., Brown, M., McGrath, J., Liu, S. & W.F. Stafford (1997) Antibodies capable of releasing diphtheria toxin in response to the low pH found in endosomes. J. Biol. Chem. 272, 27618-27622.

Raso, V., Brown, M. & J. McGrath (1997) Intracellular targeting with low pH-triggered bispecific antibodies.  J. Biol. Chem. 272, 27623-27628.

Raso, V. (1994)  Immunotargeting intracellular compartments. Analyt.l Biochem. 222, 297-304.

PubMed:
Click here for a list of publications (searches the National Library of Medicine's PubMed database.)