Lucia Rameh, Ph.D.
Scientist
Signal transduction by phosphoinositide lipids
Email: rameh at bbri.org

Research Summary
Phosphoinositides are important mediators of hormone and growth factor signals that determine cell proliferation, survival, morphology, metabolism and motility. These basic cellular functions are essential for the development and well being of complex organisms. We are currrently focusing our research on understanding the function of a novel phosphoinositide molecule, PtdIns-5-P, and the enzyme that uses it as substrate, the PI-5-P 4-kinase. Our goal is to determine how PtdIns-5-P levels are regulated in mammalian cells, to identify its cellular targets and to understand how it affects cellular function in cancer and diabetes.

Selected Publications
Mitra P, Zhang Y, Rameh LE, Ivshina MP, McCollum D, Nunnari JJ, Hendricks GM, Kerr ML, Field SJ, Cantley LC, Ross AH. A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast. J Cell Biol. 2004 Jul 19;166(2):205-11. 

Lamia KA, Peroni OD, Kim YB, Rameh LE, Kahn BB, Cantley LC. Increased insulin sensitivity and reduced adiposity in phosphatidylinositol 5-phosphate 4-kinase beta-/- mice. Mol Cell Biol. 2004 Jun;24(11):5080-7.

Chang JD, Field SJ, Rameh LE, Carpenter CL, Cantley LC. Identification and characterization of a phosphoinositide phosphate kinase homolog. J Biol Chem. 2004 Mar 19;279(12):11672-9.

Carricaburu V, Lamia KA, Lo E, Favereaux L, Payrastre B, Cantley LC, Rameh LE. The phosphatidylinositol (PI)-5-phosphate 4-kinase type II enzyme controls insulin signaling by regulating PI-3,4,5-trisphosphate degradation. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9867-72.

Field, S. J., Lamia, K. A., Rameh, L. E. & L. C. Cantley. (2002) Lipid research picks up speed on the slopes of Taos. Dev Cell 2, 407-10.

PubMed:
Click here for a list of publications (searches the National Library of Medicine's PubMed database.)