Renne Chen Lu, Ph.D.
Senior Scientist
Function-structure relationships of myosins
Email: lu at bbri.org

Research Summary
Unconventional myosins have targeted functions in different cell types.My research interest is to understand the structure and the cellular function of myosin V, which has been implicated to transport organelles in brain, skin and other tissues.

Selected Publications
Pashkova, N., Catlett, N. L., Novak, J. L., Wu, G., Lu, R., Cohen, R. E., and Weisman, L. S. (2005) Myosin V attachment to cargo requires the tight association of two functional subdomains. J. Cell Biol. 168, 359-364.

Terrak, M., Wu, G., Stafford, W. F., Lu, R. C. & R. Dominguez. (2003) Two distinct myosin light chain structures are induced by specific variations within the bound IQ motifs-functional implications. EMBO J. 22, 362-371.

Terrak, M., Otterbein, L. R., Wu, G., Palecanda, L. A., Lu, R. C. & R. Dominguez. (2002) Crystallization, X-ray characterization and selenomethionine phasing of Mlc1p bound to IQ motifs from myosin V. Acta Crystallographica. D58, 1882-1885.

Li, Y., Zhuang, S., Guo, H., Mabuchi, K., Lu, R.C. & C.A. Wang (2000) The major myosin-binding site of caldesmon residues near its N-terminal extreme. J. Biol. Chem. 275, 10989-10994.

Wu, G.-M., Wong, A., Fang, Q. & R.C. Lu (1998) Phosphorylation changes the spatial relationship between Glu124-Arg143 and Cys18/Cys165 of the regulatory light chain in smooth muscle myosin.  Biochemistry. 37, 7676-7685.

PubMed:
Click here for a list of publications (searches the National Library of Medicine's PubMed database.)