Oliver D. King, Ph.D.
Scientist
Computational biology, evolutionary dynamics, protein misfolding
Email: king at bbri.org

Research Summary
My research involves using computational and mathematical approaches to illuminate biological systems. Current projects include modeling the evolution of proteins involved in neurodegenerative disorders, and analyzing high-throughput experimental data to understand how genetics and environmental factors interact to influence phenotype. 

For more information.

Selected Publications
Steele, A. D., Hutter, G., Jackson, W. S., Heppner, F. L., Borkowski, A. W., King, O. D., Raymond, G. J., Aguzzi, A. & Lindquist, S. (2008). Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease. Proc Natl Acad Sci U S A. [Epub ahead of print]

Tian, W., Zhang, L. V., Tasan, M., Gibbons, F. D., King, O. D., Park, J., Wunderlich, Z., Cherry, J. M. & Roth, F. P. (2008). Combining guilt-by-association and guilt-by-profiling to predict Saccharomyces cerevisiae gene function. Genome Biol 9 Suppl 1, S7. [Epub ahead of print]

King, O. D. & Masel, J. (2007). The evolution of bet-hedging adaptations to rare scenarios. Theor Popul Biol, in press.

Steele, A. D., Jackson, W. S., King, O. D. & Lindquist, S. (2007). The power of automated high-resolution behavior analysis revealed by its application to mouse models of Huntington's and prion diseases. Proc Natl Acad Sci U S A 104, 1983-8.

King, O. D. & Gaborit, P. (2007). Binary templates for comma-free DNA codes. Discrete Applied Mathematics 155, 831-839.

Zhang, L. V., King, O. D., Wong, S. L., Goldberg, D. S., Tong, A. H., Lesage, G., Andrews, B., Bussey, H., Boone, C. & Roth, F. P. (2005). Motifs, themes and thematic maps of an integrated Saccharomyces cerevisiae interaction network. J Biol 4, 6.

King, O. D., Foulger, R. E., Dwight, S. S., White, J. V. & Roth, F. P. (2003). Predicting gene function from patterns of annotation. Genome Res 13, 896-904.

King, O. D. & Roth, F. P. (2003). A non-parametric model for transcription factor binding sites. Nucleic Acids Res 31, e116.

PubMed:
Click here for a list of publications (searches the National Library of Medicine's PubMed database.)