Charles P. Emerson, Jr., Ph.D., Director
Dorothy Syrigos, Administrative Assistant
Dr. Charles P. Emerson, Jr. has been Director of the Boston Biomedical Research Institute since 2003 as well as Senior Scientist. He received his A.B. from Princeton University and a Ph.D. from the University of California San Diego, followed by postdoctoral training at the University of Virginia, where he initiated his research on skeletal muscle. He has held faculty positions at the University of Virginia as Commonwealth Professor of Biology, the Fox Chase Cancer Center as Senior Scientist, and the University of Pennsylvania School of Medicine as the Joseph Leidy Professor and Chair of Cell and Developmental Biology.
He is an internationally recognized developmental biologist through his research on skeletal muscle development. His significant contributions include pioneering molecular work on the development of cell culture models to define gene regulatory mechanisms underlying skeletal muscle differentiation, and the development of cell-based gene transfer approaches that led to the identification of the muscle master regulatory genes and that continue to be used to identify stem cell regulatory genes. His recent work has focused on the functions of the muscle master regulatory genes and novel extracellular signaling regulators and their roles in the generation of the stem cells that form skeletal muscles in the embryo and that regenerate damaged adult muscles and on the developmental and genetic origins of muscle cancer stem cells in Hedgehog (Gorlin’s Syndrome) cancers.
Dr. Emerson’s research program has been funded continuously over his career by the NIH, as well as by NSF, ACS, and MDA, and he has been the recipient of NIH Career Development and Merit Awards. In addition to his academic and research leadership roles, he also has been director of two NIH training grants for graduate students and postdoctoral fellows at the University of Virginia and the University of Pennsylvania School of Medicine. Dr. Emerson currently is the Director of the BBRI-based Senator Paul D. Wellstone Cooperative Research Muscular Dystrophy Center as well as a lead Center investigator in studies to develop stem cell therapeutics to treat muscle injury and muscular dystrophy.
Henry Paulus, Ph.D., Deputy Director
Dr. Henry Paulus is an enzymologist, who received his B.A., B.S., and Ph.D. degrees from the University of Chicago, followed by postdoctoral training at the University of Cambridge and Harvard University with Nobel laureates Alexander Todd and Konrad Bloch, respectively. In 1961, he joined the Department of Biological Chemistry at the Harvard Medical School, where he initiated a very active research and teaching program leading to the rank of Associate Professor.
His research focused on the control of the synthesis of essential amino acids in bacteria and led to the discovery of several novel control mechanisms. In 1975, Dr. Paulus was offered the position of Senior Scientist at the Boston Biomedical Research Institute and he has remained in this very stimulating and collegial research environment ever since, where at times he also served as Deputy Director, Director, and Acting Director.
His current research focuses on the self-catalyzed rearrangement of proteins, known as protein splicing, and he was instrumental in elucidating the biochemical mechanism of this complex process. Protein splicing plays a critical role in the growth of Mycobacterium tuberculosis and also in certain cancers, such as pancreatic and small-cell lung cancer, and in recent years, Dr. Paulus has focused his research on the identification of protein splicing inhibitors as potential therapeutic agents for TB and cancer.
Alan L. Kaye, Chief Financial & Administrative Officer
Patricia Brouillette, Human Resources Manager
Office of Technology Transfer
Todd S. Keiller, Director of Technology Affairs
Donald Gillis, Facilities Manager
OFFICERS, TRUSTEES, TRUSTEES EMERITI, AND CORPORATORS
Jane H. Stephenson
John R. Layton
Nicholas S. Brill
Josefina Bondoc DeBaere, Ph.D.
Stuart H. Watson
Nathaniel S. Howe, Jr.
Eli Manchester, Jr.,
Charles P. Emerson, Jr., Ph.D.,
Henry Paulus, Ph.D.,
Gail F. Blout
Leah M. Cataldo, Ph.D.
David G. Conlin
Jillian Hosford Darling
Thomas R. DiBenedetto
Robert J. Engel
Douglas M. Fambrough, Ph.D.
Gregory S. Getschow
Jay Luly, Ph.D.
Joseph B. Martin, M.D., Ph.D.
Richard A. Murphy, Ph.D.
Allie F. Blodgett
Donald G. Comb, Ph.D.
John B. French
John Gergely, M.D., Ph.D., D.Sc.M.
Ernest Henderson, III
John A. Shane
William B. Tyler
SCIENTIFIC ADVISORY BOARD
Jeffrey J. Fredberg, Ph.D.
Professor of Bioengineering and Physiology
Department of Environmental Health
Harvard School of Public Health
Jonathan Garlick, D.D.S., Ph.D.
Professor of Oral and Maxillofacial Pathology
Director, Division of Cancer Biology and Tissue Engineering
Tufts University School of Dental Medicine
Marsha A. Moses, Ph.D.
Julia Dyckman Andrus Professor
Harvard Medical School, Department of Surgery
Director, Vascular Biology Program
Children’s Hospital Boston
Terence Partridge, Ph.D.
Children’s Research Institute
Research Center for Genetic Medicine
Children’s National Medical Center
Lawrence M. Schwartz, Ph.D.
Department of Biology
University of Massachusetts Amherst
Ralph Scully, M.B., B.S., Ph.D.
Associate Professor of Medicine
Harvard Medical School
Beth Israel Deaconess Medical Center
Jennifer Van Eyk, Ph.D.
Professor of Medicine
Biological Chemistry and Biomedical Engineering
Director, Johns Hopkins Bayview Proteomic Center
Johns Hopkins Bayview Medical Center
Kenneth Walsh, Ph.D.
Professor of Medicine
Boston University School of Medicine
COMMITTEE ON RESEARCH
Charles P. Emerson,Jr., Ph.D., Director and Senior Scientist
Markus Hardt, Ph.D., Scientist
Peter Jones, Ph.D., Principal Scientist
Paul Leavis, Ph.D., Senior Scientist
Jeffrey Miller, Ph.D., Senior Scientist
Henry Paulus, Ph.D., Senior Scientist
Sarah Wilcox-Adelman, Ph.D., Scientist