Technology Licensing
It is the general policy of BBRI that the results of
research of its staff and employees should be made promptly, freely and
widely available to other research workers and to the public. In most
instances, this purpose is best served by publication of all
information concerning the research and its practical applications.
However, in some cases, the application of research results can be
speeded by seeking patent protection for inventions when appropriate
and by forming partnership with industry to speed the development of
the fruits of research into procedures or products that can improve the
diagnosis and management of disease. The importance of such technology
transfer to the public interest was recognized by the US Congress
through passage of the Bayh-Dole legislation in 1980. Accordingly, BBRI
is sincerely interested in exploring partnerships with companies that
will complement its basic research programs and enable the discoveries
of its scientists to move from the research bench to the clinic as
rapidly as possible. BBRI also welcomes collaborations with scientists
from academic and other non-profit institutions.
For further information please contact:
Mr. Todd S. Keiller
Director, Technology Affairs
Boston Biomedical Research Institute
64 Grove Street
Watertown, MA 02472
Direct Phone: 508-497-2497
BBRI Phone: 617-658-7786
Fax: 508-497-0733
Email: todd.keiller@gmail.com
Patents
| Invention |
Inventor |
Patent |
Status |
Compositions and Methods for Enhancing Protein Folding
|
Takayama, Hishia |
USSN 61,426,326
FILED 12/22/10 |
Available for license |
Unique properties of stem cells --
A method for universal and specific identification and quantification of tissue-specific adult stem cells based on their unique DNA inheritance pattern.
|
Sherley, Merok |
US #7,883,891
2/8/11 |
Available for license |
Hepatocyte precursor cell lines
A method for clonal expansion of adult liver stem cells that have the ability to produce cells with mature hepatocyte properties like inducible cytochrome P450 enzymes. These cells can be engineered by gene transfer.
|
Sherley, Lee, Crane |
US #7,645,610
1/12/10 |
Available for license |
Methods for ex vivo propagation of somatic hair follicle stem cells. --
A method for mass production and clonal derivation of hair follicle stem cells.
|
Sherley, King |
US #7,655,465
2/2/10
|
Available for license |
Methods for ex vivo propagation of adult hepatic stem cells
A method for mass production and clonal derivation of human adult liver stem cells that have the ability to produce cells with mature hepatocyte properties, including secretion of human hepatocyte-specific proteins, production of human hepatocyte extracellular matrix proteins, and expression of inducible human cytochrome P450 enzymes. These cells can be engineered by gene transfer.
|
Sherley, Panchalingam |
US #7,824,912 |
Available for license |
Nucleic acid sequences associated with cell states
Universal and specific biomarkers for tissue-specific adult stem cells.
|
Sherley, Noh |
US #7,867,712
1/11/11
|
Available for license |
Method for cloning pluripotent stem cells. --
Methods for gene-free production of cells with properties of induced pluripotent stem cells.
|
Sherley, Paré |
USSN 61/266,602
12/4/09
|
Available for license |
Detecting and counting tissue specific stem cells and uses thereof
Methods for universal and specific quantification of tissue-specific adult stem cell number in complex cell preparations
|
Sherley, Huh |
USSN 61/283,485
12/4/09
|
Available for license |
| Compositions and Methods for Binding or Inactivating Grehlin |
Raso |
USSN 12/223,852
8/11/08
|
Available for license |
Methods for Identifying Modulators of Hedgehog Autoprocessing
Reagents identified by the invention can be used in the modulation of Hh autoprocessing, especially as they relate to the treatment of illnesses and diseases that are caused, at least in part, by the misregulation of Hh autoprocessing.
|
Paulus, Emerson & Ai |
USSN 11/634,300
12/5/06
|
Available for license |
| Methods and Compositions for Specific Inhibition of Protein Splicing by Small Molecules for the Treatment of Tuberculosis |
Paulus |
U.S. #7,553,832
6/30/09
|
Available for license |
| Immunological modulation of insulin-like growth factor 1 for cancer prevention/treatment and prolonging longevity |
Raso |
US # 7,749,966
7/6/10
|
Available for license |
| Leptin Peptide Antagonists for Cancer, Implantation, Preeclampsia, and Endometriosis |
Gonzalez & Leavis |
US # 7,407,929
8/5/08
US # 7,612,043
11/3/09
|
Licensed |
| Methods for Preventing or Reducing Ischemia/Reperfusion Induced Myocardial Cell Death (PUMA) |
Erhardt |
US#7,709,216
5/4/10
|
Available for license |
Inhibition of FGF Signaling via Sulf1
Methods and compositions for inhibiting FGF signaling are described. The inhibitors may stimulate stem cell growth and inhibit tumor cell growth and angiogenesis.
|
Emerson, Ai |
USSN 11/057,390
2/11/05
|
Available for license |
Collagen Extracted from Collagen-Containing Tissue
Method for collagen extraction. Collagen product may be used as cell growth matrix, synthetic skin, dressing for wounds, or membranes.
|
Davidson |
U.S.#4,983,721
U.S.#5,064,941
|
Available for license |
Cellular Uptake of Modified Peptides
Method to introduce peptides into cells and to covalently cross-link peptides to their intracellular targets.
|
Coleman |
U.S.#5,736,394 |
Available for license |
| Method for Delivering Functional Domains of Diphtheria Toxin To a Cellular Target |
Raso & Sheldon |
U.S.#5,830,478 |
Available for license |
Hybrid Reagents Capable of Selectively Releasing Molecules into Cells
Hybrid antibody system to rapidly release a toxin inside a cell.
|
Raso
|
U.S.#5,501,854
U.S.#5,603,931
U.S.#5,599,908
Foreign Patents
|
Available for license |
Heat Shock Protein Induction and Applications
Method of inducing Hsp72 production using a proteasome inhibitor.
|
Sherman |
U.S.#6,096,711 |
Available for license |
| Methods and Compositions Relating to Anthrax Pathogenesis A method assaying for inhibitors of infection by bacteria, which comprises obtaining a potential inhibitor, obtaining a calmodulin activated adenylyl cyclase exotoxin, obtaining calmodulin, admixing the potential inhibitor, the exotoxin, and the calmodulin, and assaying to determine whether or not the potential inhibitor inhibits production of cAMP by exotoxin. |
Bohm (with U. of Chicago) |
US # 7,462,472
12/9/08
|
Available for license |
Anti-idiotypic Vaccines to Elicit Catalytic Antibodies
Alternative approach for obtaining catalytic antibodies that does not require knowledge of enzyme active sites or modification of polypeptides. Potential applications to the in vivo generation of catalytic antibodies for therapeutic purposes.
|
Raso & Paulus |
U.S.#6,140,091 |
Licensed |
Immunological Control of Beta-Amyloid Levels
Vaccines to reduce the size and number of amyloid plaques or delay their appearance in the brain. (Alzheimer's disease applications)
|
Raso |
U.S. #6,582,945
U.S. #6,872,554
U.S. #7,906,626 |
Licensed |
Bispecific Monoclonal Antibodies
Chemical methodology to prepare bispecific antibodies. Broad applications in therapeutics, diagnostics, electrodes, molecular microcircuits.
|
Paulus |
U.S.#4,444,878
U.S.#5,292,668
U.S.#5,523,210
Foreign patents
|
Licensed |
| Human carcinoma antigen (HCA), HCA antibodies, HCA immunoassays and methods of imaging |
Codington |
U.S.#5,545,532 |
Licensed |
| Antibodies to human carcinoma antigen |
Codington |
U.S.#5,693,763 |
Licensed |
| Human carcinoma antigen |
Codington |
U.S.#5,808,005 |
Licensed |
Method for Generating Split, Non-transferable Genes that are able to Express an Active Protein Product
Protein splicing in trans to express a protein as two inactive fragment that can be constituted by protein splicing to produce a functional enzyme.
|
Paulus (with NE Biolabs) |
U.S. #6,858,775 |
Licensed |
|
|
