Hartmut Wohlrab, Ph.D.

Hartmut Wohlrab, Ph.D.

Senior Scientist
Membrane transport proteins, metabolism in cancer and aging, mitochondria

wohlrab@bbri.org
Phone: 617.658.7775
Fax: 617.972.1753

Research Summary

Transport (carrier) proteins embedded in the mitochondrial inner membrane provide an essential link between metabolic pathways in the cellular cytosol and the mitochondrial matrix. Their role is essential for the optimum function of oxidative phosphorylation which provides the energy currency (ATP) for the cell. Much work has been and needs to be done to understand the mechanism of how these transporters function, i.e. how do they function as homodimers or monomers. As cells are transformed into cancer, e.g. as the human ages, the mitochondria also change and are essential to cancer metabolism. Studies of these mitochondria and their transporters will lead to new cancer therapeutic agents.
 

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Selected Publications

  • Wohlrab H. Homodimeric intrinsic membrane proteins. Identification and modulation of interactions between mitochondrial transporter (carrier) subunits. Biochem Biophys Res Commun. 2010;293(4):746-750.
  • Wohlrab H. Transport proteins (carriers) of mitochondria. IUBMB Life. 2009;61(1):40-46.
  • Wohlrab H. The human mitochondrial transport/carrier protein family. Nonsynonymous single nucleotide polymorphisms (nsSNPs) and mutations that lead to human diseases. Biochim Biophys Acta. 2006;1757(9-10):1263-70.
  • Wohlrab H. The human mitochondrial transport protein family: identification and protein regions significant for transport function and substrate specificity. Biochim Biophys Acta. 2005;1709(2):157-68.
  • Wohlrab H. Novel inter- and intrasubunit contacts between transport-relevant residues of the homodimeric mitochondrial phosphate transport protein. Biochem Biophys Res Commun. 2004;320:685-688.
  • Phelps A, Wohlrab H. Homodimeric mitochondrial phosphate transport protein. Transient subunit/subunit contact site between the transport relevant transmembrane helices A. Biochemistry. 2004;43(20):6200-6207.
  • Wohlrab H, Annese V, Haefele A. Single replacement constructs of all hydroxyl, basic, and acidic amino acids identify new function and structure-sensitive regions of the mitochondrial phosphate transport protein. Biochemistry. 2002;41(9):3254-3261.

 

PubMed:
Click here for a list of publications (searches the National Library of Medicine's PubMed database.)

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