Andrew Bohm

Post-Doc 1997. Yale University/HHMI
Post-Doc 1994. U.C. Berkeley/Dept. of Energy
Ph.D. 1992. Biophysics, University of California at Berkeley
B.S. 1987. Biochemisty, State University of New York at Binghamton

Research Interests

Please see the Bohm & Harrison Home Page for a summary of my research interests and a listing of the current projects in my laboratory.

Publications

Obin, M., Leyy, B.Y., Meinke, G., Bohm, A., Lee, R.H., Gaudet, R., Hopp, J.A., Arshavsky, V.A., Willardson, B.A., Taylor, A. (2002) Ubiquination of the Trasducin beta gamma Subunit Complex. Journal of Biological Chemistry 277, 44566-44575.

Drum, C.L., Yan, S.-Z., Bard, J., Shen, Y.-Q., Lu, D., Soelaiman, S., Grabarek, Z., Bohm, A.*, Tang, W.-J*. (2002) Structural basis for the activation of the anthrax adenylyl cyclase exotoxin by calmodulin. Nature 415, 396-402.

Drum, C.L., Shen, Y., Rice, P.A., Bohm, A., Tang, W.-T. Crystallization and Preliminary X-ray Study of the Edema Factor Exotoxin Adenylyl Cyclase Domain from Bacillus Anthracis in the Presence of its activator, Calmodulin. Acta Crystallographica D57, 1881-1884.

Skiba N.P., Martemyanov, K.A., Elfeinbein, A., Hopp, J.A., Bohm, A., Simonds, W.F., and Arshavsky, V.Y. (2001) GS9-G beta 5 substrate selectivity in photoreceptors. Opposing effects of constituent domains yield high affinity of RGS interaction with the G protein-effector complex. Journal of Biological Chemistry 276:37365-72.

Drum, C.L., Yan, S.-Z., Sarac, R., Mabuchi, Y., Beckingham, K., Bohm, A., Grabarek, Z., Tang, W.-J. (2000) An Extended Conformation of Calmodulin Induces Interactions between the Structural Domains of Adenylyl Cyclase from Bacillus anthracis to Promote Catalysis. Journal of Biological Chemistry 275, 36334-340.

Bard J, Zhelkovsky AM, Helmling S, Earnest TN, Moore CL, Bohm A. (2000) Structure of yeast Poly(A) polymerase alone and in complex with 3'-dATP. Science 289, 1346-1349.

Bohm, A., Gaudet, R, Sigler, P.B. (1997) Structural aspects of heterotrimeric G-protein signalling. Current Opinions in Biotechnology 8, 480-487.

Gaudet, R., Bohm, A., Sigler, P.B. (1996) Crystal structure of the complex of transducin beta-gamma and its regulator, phosducin. Cell 87, 577-588.

Sondek, J., Bohm, A., Lambright, D.G., Hamm, H.E., Sigler, P.B. (1996) The 2.1 Angstrom crystal structure of a G-protein beta-gamma dimer. Nature 379, 369-374.

Lambright, D.G., Sondek, J., Bohm, A., Skiba, N.P., Hamm, H.E., Sigler, P.B. (1996) The 2.0 Angstrom structure of a heterotrimeric G-protein. Nature 379, 311-319.

Taylor, E.W., Fear, A.-L., Bohm, A., Kim, S.-H., Koths, K. (1994) Structure-function studies on recombinant human macrophage colony stimulating factor (M-CSF). Journal of Biological Chemistry 269, 31171-31177.

Kim, R., Holbrook, E.L, Jancarik, J., Pandit, J., Weng, X., Bohm, A., Kim, S.H. (1994) High resolution crystals and preliminary X-ray diffraction studies of catalytic RNA. Acta Crystallographica D50, 290-292.

Rozwarski, D., Bazan, F., Clore, M., Bohm, A., Hatada, M., Wlodawer, A., Karplus, A. (1994) Structural comparisons among the short chain helical cytokines. Structure 2, 159-173.

Harrison, C.J., Bohm, A., Nelson, H.C.M. (1994) Crystal structure of the DNA binding domain of the heat shock transcription factor. Science 263, 224-227.

Pandit, J., Bohm, A., Jancarik, J., Halenbeck, R., Koths, K., Kim, S.H. (1992) Three dimensional structure of dimeric human recombinant macrophage colony stimulating factor. Science 258, 1358-1362.