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Postdoc Positions
Post-doctoral Research Opportunities
Positions are immediately available for candidates with Ph.D., M.D., M.D./Ph.D., or equivalent degrees in life science disciplines who seek superior biomedical research training. Opportunities currently exist with faculty in each of BBRI’s four leading programs.
CANCER BIOLOGY
Charles P. Emerson: Signaling and transcriptional regulatory networks that control stem cell growth and differentiation in tissue regeneration and cancer
Kent Nybakken: Novel post-transcriptional regulators of Hedgehog signaling in normal development and cancer
INTEGRATIVE PROTEIN BIOLOGY
Markus Hardt: Mass spectrometry-based investigations of diagnostic proteolytic processes in oral diseases
Oliver King: Computational biology related to protein misfolding and neurodegeneration
CARDIOVASCULAR BIOLOGY
Zenon Grabarek: Cardiac muscle contraction regulation mechanisms in familial hypertrophic cardiomyopathy
REGENERATIVE BIOLOGY
Moonkyoung Um: Mechanisms and signatures of neurodegenerative diseases in mouse models
Martin Duennwald: Molecular mechanisms of neurodegeneration in tissue culture and yeast models
Janice Dominov: Skeletal muscle degeneration and stem cell repair mechanisms in mouse models of muscular dystrophy
James L. Sherley: Production of therapeutic adult stem cells and adult stem cell molecular biology
For additional information: http://www.bbri.org
BBRI provides a unique training environment focused expressly on the career development of post-doctoral associates and supported by state-of-the-art equipment and facilities. Competitive compensation and benefit packages are available, including retirement benefits for appointees who meet the eligibility requirements.
To apply: Mail statement of research interests and career goals, curriculum vitae, and contact information for three references to attention of faculty members of interest at: 64 Grove Street, Watertown, MA 02472 USA.
BBRI is an Equal Opportunity Employer. Hiring is contingent upon eligibility to work in the United States.
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Job Title: Postdoctoral Fellow position in Functional Proteomics
A postdoctoral position is available in October 2008, to study proteolytic processes using mass spectrometry. Candidates should have a Ph.D., in the fields of biochemistry, analytical chemistry, mass spectrometry or bioinformatics. The study will focus on characterizing proteolytic enzyme and their peptide products in complex biological samples and diseases such as oral squamous cell carcinoma and Sjögren’s syndrome using novel, functional and activity-based mass spectrometry approaches.
The Boston Biomedical Research Institute is a dynamic, independent, non-profit research institute located within minutes of all of the Boston area’s major universities and medical centers. In addition to the Integrative Protein Biology Program, BBRI has recently launched and expended three disease-focused research programs in Cancer Biology, Cardiovascular Biology, and Regenerative Biology. These new research programs provide unique opportunities for resources and collaboration. BBRI is comprised of a diverse and highly motivated group of structural biologists, biochemists, molecular biologists, cell biologists and mathematical biologists, who utilize state-of-the-art technologies and innovative approaches to further our understanding of molecular mechanisms relevant to biomedicine.
Salary will be set according to NIH Standards and a comprehensive benefits package will be provided.
To apply, send CV, cover letter with summary of research interests, and three letters of reference to: Markus Hardt, Ph.D. (mhardt@cgl.ucsf.edu).
BBRI is an Equal Opportunity Employer.
Hiring is contingent upon eligibility to work in the United States.
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Job Title: MCB Core Scientist
Responsibilities of the MCB Core Scientist are laboratory research and management of a cell and molecular lab and the associated instrumentation and facilities of an NIH Center for the study of human muscle disease. Primary research activities and functions of the Core Scientist include: cell culture, histological, cell biological and molecular research on the growth and differentiation properties of diseased and normal muscle stem cells derived from human muscle biopsies; cell repository and database management; development and use application of molecular, cell biological and immunological methods and reagents for muscle stem cell research; training of Center investigators in laboratory research methods, including FACS cell sorting, RT-PCR, cell culture, and cell imaging; and supervision a Core laboratory technician, when funding is available. The MCB Core Scientist will have ongoing collaborative research and training interactions with clinicians, scientists, trainees, bioinformaticists, and industrial partners associated with the Center and will participate in the preparation and authorship of research publications resulting from Core research activities and make presentations in Center research forums and at national research meetings.
Education and experience: Masters or Ph.D. degree, with at least 5 years of laboratory research experience in academic or industry labs.
To apply, please send a resume or CV, a cover letter stating your scientific interests and experience, and three references with contact information to:
Charles P. Emerson, Jr., Ph.D.
Director and Senior Scientist
Boston Biomedical Research Institute
64 Grove Street
Watertown, MA 02472
Email: emersonc@bbri.org
The Boston Biomedical Research Institute (BBRI) is an independent, non-profit research institute in Watertown, Massachusetts. The Institute is dedicated to basic biomedical research to promote the understanding, treatment and prevention of human diseases, and provides state-of-the-art research facilities, a collegial working environment and excellent employee benefits.
BBRI is an Equal Opportunity Employer.
Hiring is contingent upon eligibility to work in the United States.
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Job Title: Postdoctoral Fellow position in Signaling and Cancer Biology
The Laboratory of Dr. Kent Nybakken has an immediate opening for a postdoctoral researcher interested in elucidating the role of newly discovered components of the Hedgehog signaling Pathway. We are examining the mechanism by which alternative splicing factors, phosphatases, and acetylases regulate Hedgehog signaling in normal development and cancer using both Drosophila and vertebrate model systems. We use a combination of genetics, biochemistry, cell biology, and high-throughput cell-based assays to determine how these factors interact with known components of the Hedgehog pathway.
The Boston Biomedical Research Institute (BBRI) is an independent, non-profit research institute located near Harvard Square and Boston. The Institute is dedicated to basic biomedical research and provides state-of-the-art facilities (including new confocal microscope, mass spec, and HPLC's) and excellent salary and benefit packages for postdoctoral fellows.
Please send a CV, cover letter, statement of research interests, and the names and contact information for at least three references to:
Kent Nybakken, Ph.D.
Boston Biomedical Research Institute
64 Grove Street
Watertown, MA 02472
Email: nybakken@bbri.org
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Job Title: Postdoctoral Fellow position in Adult-Derived Stem Cell Genomics
Applicants with expertise in cellular and molecular biology techniques and bioinformatics analyses are sought to conduct post-doctoral, independent research to apply innovative genomics strategies to developing a new biotechnology for identifying
adult-derived stem cells. A Ph.D., M.D., M.D./Ph.D., or doctoral degree equivalent is required.
Applicants should forward a statement of research and career goals and CV; and have three letters of recommendation sent by regular mail to:
James L. Sherley, M.D., Ph.D.
Boston Biomedical Research Institute
64 Grove Street
Watertown, MA 02472
BBRI is an Equal Opportunity Employer.
Hiring is contingent upon eligibility to work in the United States.
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Job Title: Postdoctoral Fellow in Degenerative Disease and Regenerative Biology
A postdoctoral position is available to study skeletal muscle degeneration and repair in mouse models of muscular dystrophy. Candidates should have a Ph.D. in cell, molecular or developmental biology and have strong expertise in cell biology and molecular techniques along with experience in muscle biology and analysis of mouse disease models. Studies will focus on the role of apoptosis regulators in controlling muscle cell death and analysis of muscle stem cell populations responsible for muscle repair. Recent work from the lab is described in Human Molecular Genetics, 2005, 14:1029-1040 and Journal of Clinical Investigation, 2004, 114:1635-1639.
BBRI (www.bbri.org) is an independent, non-profit research institute, in Watertown, Massachusetts, just two miles from Harvard Square. The Institute is dedicated to basic biomedical research, and offers a highly collegial environment, state-of-the-art facilities, and excellent employee benefits.
To apply, send a CV, a summary of research interests, and the names of three references to Dr. Janice Dominov at dominov@bbri.org
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Job Title: Postdoctoral Fellow in Cardiac Biology
The position requires Ph.D. preferentially in Cardiovascular or Cell/Molecular Biology. The candidate will develop novel therapeutic strategies to cure heart diseases by analyzing cell death and hypertrophy in a mouse model conditionally overexpressing MDM2 in the heart in a tetracycline-inducible manner. The study is based on our recently published papers centered on the p53 related proteins MDM2 and Puma [Am J Physiol Heart Circ Physiol. [2006) 291:52-60; J Biol Chem. (2006) 281:3679-89; Mol Cell. (2005) 20:539-50]. The candidate’s salary is according to the NIH scale.
Please send resume to Peter Erhardt, M.D., Ph.D. E-mail: erhardt@bbri.org
The Boston Biomedical Research Institute (BBRI) is dedicated to basic biomedical research to promote the understanding, treatment and prevention of specific human diseases. BBRI is an independent, not-for-profit, academic institution. It provides an extensive benefit package to all employees.
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