Postdoc Positions

Job Title: Postdoctoral Scientist, Neurodegeneration and Aging
In the laboratory of Martin Duennwald
Job Description: A postdoctoral position is immediately available for candidates with Ph.D., M.D., M.D./Ph.D., or equivalent degrees in life science disciplines (preferably cell biology, biochemistry, molecular biology)  who seek superior biomedical research training in the field of protein misfolding, neurodegeneration, protein homeostasis and aging, using a combination of genetic, cell biological, and biochemical approaches.

Boston Biomedical Research Institute (BBRI) is an independent, non-profit, research institute located in Watertown, Massachusetts.  The Institute is dedicated to basic biomedical research to promote the understanding, treatment and prevention of human diseases. BBRI provides state-of-the art research facilities, a collegial working environment, excellent employee benefits and a unique training environment focused expressly on the career development of post-doctoral associates.

BBRI is an Equal Opportunity Employer.  Hiring is contingent upon eligibility to work in the United States.

To apply: E-mail statement of research interests and career goals, curriculum vitae, and contact information for three references to: duennwald@bbri.org

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Job Title: Postdoctoral Scientist, Cardiovascular Program
Job Description: A postdoctoral scientist position is available in the laboratory of Dr. Noriaki Ikemoto at Boston Biomedical Research Institute (www.bbri.org). This is a two year, grant-supported position that will begin in September, 2009 and depends on final budgetary approval.

The research focus of the laboratory is on cardiovascular disease and its pharmacological treatment. Our laboratory uses an integrated approach of biochemistry, fluorescence spectroscopy, confocal microscopy, molecular imaging, cell culture and animal model to identify and characterize key proteins involved in the pathogenic processes of cardiac disease (e.g. hypertrophy and arrhythmia) and to develop novel therapeutic strategies. 

Boston Biomedical Research Institute is an independent, non-profit, research institute located in Watertown, Massachusetts.  The Institute is dedicated to basic biomedical research to promote the understanding, treatment and prevention of human diseases, and provided state-of-the art research facilities, a collegial working environment and excellent employee benefits.

Education and Experience: Ph.D. or M.D. with strong background and past achievements in cell biology, confocal microscopy, proteomics are particularly encouraged. 

Contact: Please provide a summary statement how the applicant’s research interests might fit to the mission goal of the laboratory, CV, and contact information for three references to the e-mail address listed below.

Noriaki Ikemoto, Ph.D.
Cardiovascular Research Program
Boston Biomedical Research Institute
64 Grove Street, Watertown, Mass. USA
E-mail: ikemoto@bbri.org

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Job Title: Postdoctoral Fellow in Phosphoinositide Signaling
Job Description:A postdoctoral position is available in the research laboratory of Dr. Lucia Rameh at the Boston Biomedical Research Institute (BBRI) to study mechanisms of phosphoinositide regulation and function, and PI3Kinase signaling in disease. Candidates should have a Ph.D., M.D., or equivalent in the fields of biochemistry, cellular and molecular biology, or related areas.

BBRI is an independent, non-profit research institute located in Watertown near the Cambridge line and minutes from Harvard Square. The Institute is dedicated to basic biomedical research and provides state-of-the-art facilities and excellent benefit packages for postdoctoral fellows.

To apply, please send cover letter, curriculum vitae and references to Dr. Lucia Rameh rameh@bbri.org.

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Job Title: Postdoctoral Fellow position in Functional Proteomics
A postdoctoral position is available in October 2008, to study proteolytic processes using mass spectrometry. Candidates should have a Ph.D., in the fields of biochemistry, analytical chemistry, mass spectrometry or bioinformatics. The study will focus on characterizing proteolytic enzyme and their peptide products in complex biological samples and diseases such as oral squamous cell carcinoma and Sjögren’s syndrome using novel, functional and activity-based mass spectrometry approaches. 

The Boston Biomedical Research Institute is a dynamic, independent, non-profit research institute located within minutes of all of the Boston area’s major universities and medical centers. In addition to the Integrative Protein Biology Program, BBRI has recently launched and expended three disease-focused research programs in Cancer Biology, Cardiovascular Biology, and Regenerative Biology. These new research programs provide unique opportunities for resources and collaboration. BBRI is comprised of a diverse and highly motivated group of structural biologists, biochemists, molecular biologists, cell biologists and mathematical biologists, who utilize state-of-the-art technologies and innovative approaches to further our understanding of molecular mechanisms relevant to biomedicine.

Salary will be set according to NIH Standards and a comprehensive benefits package will be provided.

To apply, send CV, cover letter with summary of research interests, and three letters of reference to: Markus Hardt, Ph.D. (mhardt@cgl.ucsf.edu).

BBRI is an Equal Opportunity Employer.
Hiring is contingent upon eligibility to work in the United States.

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Job Title:  Postdoctoral Fellow position in Adult-Derived Stem Cell Genomics
Applicants with expertise in cellular and molecular biology techniques and bioinformatics analyses are sought to conduct post-doctoral, independent research to apply innovative genomics strategies to developing a new biotechnology for identifying adult-derived stem cells. A Ph.D., M.D., M.D./Ph.D., or doctoral degree equivalent is required. 

Applicants should forward a statement of research and career goals and CV; and have three letters of recommendation sent by regular mail to:

James L. Sherley, M.D., Ph.D.
Boston Biomedical Research Institute
64 Grove Street
Watertown, MA 02472

BBRI is an Equal Opportunity Employer.
Hiring is contingent upon eligibility to work in the United States.

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Job Title: Postdoctoral Fellow in Cardiac Biology
The position requires Ph.D. preferentially in Cardiovascular or Cell/Molecular Biology. The candidate will develop novel therapeutic strategies to cure heart diseases by analyzing cell death and hypertrophy in a mouse model conditionally overexpressing MDM2 in the heart in a tetracycline-inducible manner. The study is based on our recently published papers centered on the p53 related proteins MDM2 and Puma [Am J Physiol Heart Circ Physiol. [2006) 291:52-60; J Biol Chem. (2006) 281:3679-89; Mol Cell. (2005) 20:539-50]. The candidate’s salary is according to the NIH scale.

Please send resume to Peter Erhardt, M.D., Ph.D. E-mail: erhardt@bbri.org

Boston Biomedical Research Institute (BBRI) is dedicated to basic biomedical research to promote the understanding, treatment and prevention of specific human diseases. BBRI is an independent, not-for-profit, academic institution. It provides an extensive benefit package to all employees.

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Post-doctoral Research Opportunities
Positions are immediately available for candidates with Ph.D., M.D., M.D./Ph.D., or equivalent degrees in life science disciplines who seek superior biomedical research training.  Opportunities currently exist with faculty in each of BBRI’s four leading programs.

CANCER BIOLOGY
Charles P. Emerson: Signaling and transcriptional regulatory networks that control stem cell growth and differentiation in tissue regeneration and cancer
Kent Nybakken: Novel post-transcriptional regulators of Hedgehog signaling in normal development and cancer

INTEGRATIVE PROTEIN BIOLOGY
Markus Hardt: Mass spectrometry-based investigations of diagnostic proteolytic processes in oral diseases
Oliver King: Computational biology related to protein misfolding and neurodegeneration

CARDIOVASCULAR BIOLOGY
Zenon Grabarek: Cardiac muscle contraction regulation mechanisms in familial hypertrophic cardiomyopathy

REGENERATIVE BIOLOGY
Moonkyoung Um: Mechanisms and signatures of neurodegenerative diseases in mouse models
Martin Duennwald: Molecular mechanisms of neurodegeneration in tissue culture and yeast models
Janice Dominov: Skeletal muscle degeneration and stem cell repair mechanisms in mouse models of muscular dystrophy
James L. Sherley: Production of therapeutic adult stem cells and adult stem cell molecular biology

BBRI provides a unique training environment focused expressly on the career development of post-doctoral associates and supported by state-of-the-art equipment and facilities. Competitive compensation and benefit packages are available, including retirement benefits for appointees who meet the eligibility requirements.

To apply: Mail statement of research interests and career goals, curriculum vitae, and contact information for three references to attention of faculty members of interest at: 64 Grove Street, Watertown, MA 02472 USA.

BBRI is an Equal Opportunity Employer.  Hiring is contingent upon eligibility to work in the United States.